((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol

Base Information

Chemical Name:((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol
CAS No.:1198077-71-2
Molecular Formula:C₂₄H₃₉NO₄Si
Molecular Weight:433.663
Hs Code.:

Synonyms:((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol

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Chemical Property of ((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol

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Technology Process of ((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol

There total 1 articles about ((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1198077-69-8
N-benzyl-O-(tert-butyldimethylsilyl)-N-[(S)-(3,4-dihydro-2H-pyran-6-yl)((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl]hydroxylamine

: 1198077-71-2
((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -30 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol902354f DOI:10.3762/bjoc.6.75

Reference yield: 78.0%

: 1198077-71-2
((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol

: 100-39-0
benzyl bromide

: 1198077-72-3
N-benzyl-N-((7S,8S)-7-(benzyloxymethyl)-5,5-dimethyl-3,4,5,6,7,8-hexahydropyrano[4,3-b]pyran-8-yl)-O-(tert-butyldimethylsilyl)hydroxylamine

Guidance literature:: ((7S,8S)-8-(benzyl(tert-butyldimethylsilyloxy)amino)-5,5-dimethyl-2,3,4,5,7,8-hexahydropyrano[4,3-b]pyran-7-yl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol902354f