p-bromophenyl formate

Base Information

• Chemical Name: p-bromophenyl formate
• CAS No.: 4525-62-6
• Molecular Formula: C₇H₅BrO₂
• Molecular Weight: 201.019
• Mol file: 4525-62-6.mol

Synonyms:p-bromophenyl formate

Chemical Property of p-bromophenyl formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-bromophenyl formate

There total 8 articles about p-bromophenyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-bromo-benzaldehyde (1122-91-4) → p-bromophenyl formate (4525-62-6)

Guidance literature:

With water; difluoro[4-(trifluoromethyl)phenyl]-λ³-bromane; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja104330g

Reference yield: 60.0%

formic acid (64-18-6) + 4-bromo-phenol (106-41-2) → p-bromophenyl formate (4525-62-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; acetic anhydride; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/cctc.201600165

Reference yield: 37.0%

4-bromo-phenol (106-41-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → p-bromophenyl formate (4525-62-6)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 20 ℃; for 6h; chemoselective reaction;

DOI:10.1080/00397911.2016.1168450

upstream raw materials:

4'-(4-Bromophenoxy)spirodioxetane>

formic acid

4-bromo-phenol

4-bromo-benzaldehyde

Downstream raw materials:

1-bromo-4-(difluoromethoxy)benzene

4-bromo-phenol

4-methoxyformanilide

Refernces

• 1、 Iron, Mark A.,Khenkin, Alexander M.,Neumann, Ronny,Somekh, Miriam. "The formyloxyl radical: Electrophilicity, C-H bond activation and anti-Markovnikov selectivity in the oxidation of aliphatic alkenes". . p. 11584 - 11591. Retrieved 2020/11/23.
• 2、 Batuta, Shaikh,Ali, Md. Ashif,Chatterjee, Anirban,Alam, Md. Niharul,Das, Sreeparna,Mandal, Debabrata,Begum, Naznin Ara. "Understanding the efficacy of N,N-dimethylformamide and oxalyl chloride combination as chemoselective O-formylating agent: An unified experimental and theoretical study". supporting information. p. 692 - 700. Retrieved 2016/06/08.