N-(4-Methoxyphenyl)formamide

Base Information

• Chemical Name: N-(4-Methoxyphenyl)formamide
• CAS No.: 5470-34-8
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2924299090
• European Community (EC) Number: 226-802-2
• NSC Number: 26220
• DSSTox Substance ID: DTXSID30203163
• Nikkaji Number: J149.389B
• Wikidata: Q83076516
• ChEMBL ID: CHEMBL3252138
• Mol file: 5470-34-8.mol

Synonyms:N-(4-Methoxyphenyl)formamide;5470-34-8;4'-Methoxyformanilide;p-Formanisidide;Formamide, N-(4-methoxyphenyl)-;EINECS 226-802-2;AI3-18915;p-formamido anisole;NSC26220;4-Methoxyformanilide;4-methoxy formanilide;4-Methoxyphenylformamide;N-Formyl-4-methoxyaniline;4-Methoxyphenylformamide #;SCHEMBL225907;N-(4-methoxyphenyl)-formamide;CHEMBL3252138;DTXSID30203163;MFCD00086774;N-(4-Methoxyphenyl)formamide, 97%;NSC 26220;NSC-26220;AKOS013153464;CS-0197277;FT-0722230;M1623;D91515;A870377

Chemical Property of N-(4-Methoxyphenyl)formamide

Chemical Property:

• Melting Point: 78-82 °C(lit.)
• Boiling Point: 159 °C / 5mmHg
• PKA: 14.41±0.70(Predicted)
• Flash Point: 150.5°C
• PSA: 38.33000
• Density: 1.16g/cm³
• LogP: 1.97240
• Solubility.: soluble in Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

98%,99%, ^*data from raw suppliers

4''-Methoxyformanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC=O

Technology Process of N-(4-Methoxyphenyl)formamide

There total 115 articles about N-(4-Methoxyphenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formic acid (64-18-6) + 4-methoxy-aniline (104-94-9) → 4-methoxyformanilide (5470-34-8)

Guidance literature:

In toluene; Reflux;

DOI:10.1002/adsc.201000795

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + 4-methoxy-aniline (104-94-9) → 4-methoxyformanilide (5470-34-8)

Guidance literature:

With phenylsilane; C₁₄H₂₄N₄Si*HI; In benzene-d6; at 60 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acscatal.0c03795

Reference yield: 98.0%

formic acid (64-18-6) + para-methoxynitrobenzene (100-17-4) → 4-methoxyformanilide (5470-34-8)

Guidance literature:

With silver nanoparticles decorated mesoporous 1,3,5-triformylphloroglucinol-DMB covalent organic framework nanomaterial; In water; at 20 ℃; for 2h; Catalytic behavior; Irradiation; Green chemistry;

DOI:10.1016/j.mcat.2020.111050

upstream raw materials:

formic acid

p-anisidine hydrochloride

4-methoxy-aniline

formamide

Downstream raw materials:

1-(4-methoxyphenyl)-2-methylpyrrolidine

N,N'-bis(4-methoxyphenyl)iminoformamide

N,N'-bis(4-methoxyphenyl)urea

N-acetyl-N-(4-methoxybenzyl)-α,α-diethylglycine 4-methoxyphenyl amide

Refernces

• 1、 Zhang, Fengcai,Sang, Xinpeng,Zhou, Yuqiao,Cao, Weidi,Feng, Xiaoming. "Enantioselective Synthesis of Azetidines through [3 + 1]-Cycloaddition of Donor-Acceptor Aziridines with Isocyanides". supporting information. p. 1513 - 1517. Retrieved 2022/03/01.
• 2、 Datta Khanal, Hari,Mishra, Kanchan,Rok Lee, Yong. "Facile N-Formylation of Amines on Magnetic Fe3O4?CuO Nanocomposites". . p. 4477 - 4484. Retrieved 2021/08/30.