N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide

Base Information

• Chemical Name: N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide
• CAS No.: 1255639-64-5
• Molecular Formula: C₁₆H₁₃F₃N₂O₂
• Molecular Weight: 322.287
• Mol file: 1255639-64-5.mol

Synonyms:N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide

Chemical Property of N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide

There total 3 articles about N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(trifluoromethyl)benzoic acid hydrazide (339-59-3) + 4-methoxy-benzaldehyde (123-11-5) → N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide (1255639-64-5)

Guidance literature:

In methanol; at 20 ℃; for 2.08333h; Reflux;

DOI:10.1016/j.bmcl.2017.10.050

Reference yield:

methyl 4-(trifluoromethyl)benzoate (2967-66-0) → N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide (1255639-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / Reflux

2: methanol / Reflux

With hydrazine hydrate; In methanol; ethanol;

DOI:10.3390/molecules26040989

Reference yield:

4-trifluoromethylbenzoic acid (455-24-3) → N'-(4-methoxybenzylidene)-4-(trifluoromethyl)benzohydrazide (1255639-64-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

3: methanol / Reflux

With hydrazine hydrate; sulfuric acid; In methanol; ethanol;

DOI:10.3390/molecules26040989

upstream raw materials:

4-(trifluoromethyl)benzoic acid hydrazide

4-methoxy-benzaldehyde

methyl 4-(trifluoromethyl)benzoate

4-trifluoromethylbenzoic acid

Downstream raw materials:

C₂₀H₁₇F₃N₂O₃