1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine

Base Information

• Chemical Name: 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine
• CAS No.: 1436412-03-1
• Molecular Formula: C₂₂H₃₁NO₄
• Molecular Weight: 373.492
• Mol file: 1436412-03-1.mol

Synonyms:1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine

Chemical Property of 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine

There total 2 articles about 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine (1436412-02-0) + benzyl chloroformate (501-53-1,94274-21-2) → 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine (1436412-03-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol4010917

Reference yield:

C26H39NO3 → 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine (1436412-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lead(IV) tetraacetate / chloroform / 1 h / -50 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

With lead(IV) tetraacetate; potassium carbonate; In tetrahydrofuran; chloroform; water;

DOI:10.1021/ol4010917

Reference yield:

1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine (1436412-03-1) → 1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-2R-formylmethyl-4R-methylpiperidine (1436412-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 13 h / 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/ol4010917

upstream raw materials:

6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-vinyl-piperidine

benzyl chloroformate

Downstream raw materials:

1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-2R-formylmethyl-4R-methylpiperidine

1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-4R-methyl-2R-(2-oxo-propyl)piperidine

C₂₃H₃₅NO₅

1-benzyloxycarbonyl-6S-(4,4-ethylenedioxybutyl)-2R-hydroxyethyl-4R-methylpiperidine