4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

Base Information

Chemical Name:4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate
CAS No.:1355066-40-8
Molecular Formula:C₂₂H₁₈ClF₂NO₄
Molecular Weight:433.839
Hs Code.:

Synonyms:4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

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Chemical Property of 4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

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Technology Process of 4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

There total 6 articles about 4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1355066-41-9
5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

: 1354960-66-9
4-methylphenyl 2,4,5-trifluorobenzoate

: 1355066-40-8
4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1355066-40-8
4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 5 - 20 °C

1.2: 18 h / Reflux

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C

3.1: peracetic acid; acetic acid / 4 h / 5 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

With peracetic acid; sodium hydride; potassium carbonate; acetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; n-heptane; dimethyl sulfoxide;

Reference yield:

: 282723-22-2
2-Isopropoxy-3-chloropyridine

: 1355066-40-8
4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C

2: peracetic acid; acetic acid / 4 h / 5 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

With peracetic acid; potassium carbonate; acetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In n-heptane; dimethyl sulfoxide;