1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane

Base Information

Chemical Name:1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane
CAS No.:156329-87-2
Molecular Formula:C₁₄H₂₀Si
Molecular Weight:216.398
Hs Code.:
DSSTox Substance ID:DTXSID501240216

Synonyms:DTXSID501240216;1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane;156329-87-2

Suppliers and Price of 1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:2
Exact Mass:216.133427172
Heavy Atom Count:15
Complexity:248

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C[Si](C)(C)C12CC(C1)(C2)C3=CC=CC=C3

Technology Process of 1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane

There total 7 articles about 1-Phenyl-3-(trimethylsilyl)bicyclo[1.1.1]pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 75-77-4
chloro-trimethyl-silane

: 127321-10-2
1-iodo-3-phenylbicyclo<1.1.1>pentane

: 156329-87-2
1-phenyl-3-(trimethylsilyl)bicyclo<1.1.1>pentane

Guidance literature:: With tert.-butyl lithium; In diethyl ether; pentane; 1.) -78 deg C, 10 min., 2.) room temp.;
DOI:10.1021/jo00090a015

Reference yield:

: 591-50-4
iodobenzene

: 156329-87-2
1-phenyl-3-(trimethylsilyl)bicyclo<1.1.1>pentane

Guidance literature:: Multi-step reaction with 5 steps

1: petroleum ether / 5 h / Irradiation

2: ter-butyllithium / pentane / Ambient temperature

3: 94 percent / DCC

4: 93 percent / CF₃CH₂I / Irradiation

5: 92 percent / tert-butyllithium / diethyl ether; pentane / 1.) -78 deg C, 10 min., 2.) room temp.

With 1,1,1-trifluoro-2-iodoethane; tert.-butyl lithium; dicyclohexyl-carbodiimide; In diethyl ether; Petroleum ether; pentane;
DOI:10.1021/jo00090a015

Reference yield:

: 83249-10-9
3‐(methoxycarbonyl)bicyclo[1.1.1]pentane‐1‐carboxylic acid

: 156329-87-2
1-phenyl-3-(trimethylsilyl)bicyclo<1.1.1>pentane

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / Pb(OAc)4 / 6 h / 80 °C

2: aq. NaOH

3: 94 percent / DCC

4: 93 percent / CF₃CH₂I / Irradiation

5: 92 percent / tert-butyllithium / diethyl ether; pentane / 1.) -78 deg C, 10 min., 2.) room temp.

With lead(IV) acetate; sodium hydroxide; 1,1,1-trifluoro-2-iodoethane; tert.-butyl lithium; dicyclohexyl-carbodiimide; In diethyl ether; pentane;
DOI:10.1021/jo00090a015