2-amino-7-benzyloxy-1-tetralone hydrochloride

Base Information

• Chemical Name: 2-amino-7-benzyloxy-1-tetralone hydrochloride
• CAS No.: 2472-15-3
• Molecular Formula: C₁₇H₁₇NO₂*ClH
• Molecular Weight: 303.788
• Mol file: 2472-15-3.mol

Synonyms:2-amino-7-benzyloxy-1-tetralone hydrochloride

Chemical Property of 2-amino-7-benzyloxy-1-tetralone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-7-benzyloxy-1-tetralone hydrochloride

There total 5 articles about 2-amino-7-benzyloxy-1-tetralone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime (116906-99-1) → 2-amino-7-benzyloxy-1-tetralone hydrochloride (2472-15-3)

Guidance literature:

7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime; With potassium ethoxide; In ethanol; benzene; at 0 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; In water;

DOI:10.1016/j.tetlet.2013.11.113

Reference yield:

7-hydroxy-1-tetralone (22009-38-7) → 2-amino-7-benzyloxy-1-tetralone hydrochloride (2472-15-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; pyridine / 16 h / 120 °C

3: pyridine / 16 h / 20 °C

4: potassium ethoxide / ethanol; benzene / 5 h / 0 °C / Inert atmosphere

With pyridine; hydroxylamine hydrochloride; potassium ethoxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.tetlet.2013.11.113

Reference yield:

7-Methoxy-1-tetralone (6836-19-7) → 2-amino-7-benzyloxy-1-tetralone hydrochloride (2472-15-3)

Guidance literature:

Multi-step reaction with 5 steps

1: aluminum (III) chloride / toluene / 1 h / 110 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: hydroxylamine hydrochloride; pyridine / 16 h / 120 °C

4: pyridine / 16 h / 20 °C

5: potassium ethoxide / ethanol; benzene / 5 h / 0 °C / Inert atmosphere

With pyridine; aluminum (III) chloride; hydroxylamine hydrochloride; potassium ethoxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1016/j.tetlet.2013.11.113

upstream raw materials:

7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime

7-Methoxy-1-tetralone

7-hydroxy-1-tetralone

7-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one

Downstream raw materials:

(+)-N-acetyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine-9-ol triisopropylsilyl ether

trans-2-amino-7-benzoxy-1-tetraol

(1S,2R)-2-Amino-7-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-ol