116906-99-1

Basic information

• Product Name: 7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime
• Synonyms: 7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime
• CAS NO: 116906-99-1
• Molecular Weight: 421.517
• Mol File: 116906-99-1.mol

Chemical Properties

• CAS DataBase Reference: 7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime(116906-99-1)
• EPA Substance Registry System: 7-benzyloxy-3,4-dihydro(2H)-naphthalen-1-one-O-[(4-methylphenyl)sulfonyl]oxime(116906-99-1)

Safety Data

• Hazardous Substances Data: 116906-99-1(Hazardous Substances Data)

Upstream product

• 6836-19-7 7-Methoxy-1-tetralone 
• 100-44-7 benzyl chloride 
• 22009-38-7 7-hydroxy-1-tetralone 
• 32263-64-2 7-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one 
• 116885-91-7 7-benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1034706-81-4 (+)-N-acetyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine-9-ol triisopropylsilyl ether 
• 2451-66-3 trans-2-amino-7-benzoxy-1-tetraol 
• 2472-15-3 2-amino-7-benzyloxy-1-tetralone hydrochloride 

Relevant articles and documents

Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: Preliminary PET imaging study with [3-11C]-(+)PHNO

Carbon-11 labeled (+)-4-[1-11C]propyl-3,4,4a,5,6,10b-hexahydro- 2H-naphtho[1,2-b][1,4]oxazin-9-ol ([1-11C]-(+)-PHNO) is a dopamine D3-preferring agonist radiopharmaceutical used for medical imaging by positron emission tomography (PET). We report the synthesis of (+)-PHNO using supercritical fluid chromatography for enantiomeric resolution of its norpropyl derivative, HNO, followed by propylation. (+)-HNO was used to prepare the radiolabeling precursor, (+)-trans-4-acetyl-9-triisopropylsilyloxy-2,3,4a,5,6, 10b-hexahydro-4H-naphth[1,2b][1,4]oxazine, in 12 steps. Modifications to the labeling procedure were made to ensure consistent preparation of [3- 11C]-(+)-PHNO via [11C]CH3I. A preliminary PET imaging study was carried out with this tracer in an attempt to image dopamine receptors in brown adipose tissue (brown fat) in vivo.

ANTIPROLIFERATIVE BENZO [B] AZEPIN- 2 - ONES

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3 and R4 are described in this application, and methods of using said compounds in the treatment of cancer.