4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

Base Information

• Chemical Name: 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone
• CAS No.: 54087-52-4
• Molecular Formula: C₁₉H₁₉ClN₂O₂
• Molecular Weight: 342.825

Synonyms:4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

Chemical Property of 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

Chemical Property:

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Technology Process of 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

There total 1 articles about 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-amino-phenyl)-4,4-dimethyl-1,4-dihydro-2H-isoquinolin-3-one (40119-29-7) + chloroacetyl chloride (79-04-9) → 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone (54087-52-4)

Guidance literature:

With triethylamine; In acetic acid;

Reference yield: 74.8%

4-phenyl-1-piperazine (92-54-6) + 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone (54087-52-4) → 4,4-dimethyl-1-<4'-(N-phenylpiperazinylacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone (133388-06-4)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; for 7h; Ambient temperature;

Reference yield: 72.6%

1-phenylmethylpiperazine (2759-28-6) + 4,4-dimethyl-1-<4'-(chloroacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone (54087-52-4) → 4,4-dimethyl-1-<4'-(N-benzylpiperazinylacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone (133388-08-6)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; for 15h; Ambient temperature;

upstream raw materials:

1-(4-amino-phenyl)-4,4-dimethyl-1,4-dihydro-2H-isoquinolin-3-one

chloroacetyl chloride

Downstream raw materials:

4,4-dimethyl-1-<4'-(piperazinylacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

4,4-dimethyl-1-<4'-(N-methylpiperazinylacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

4,4-dimethyl-1-<4'-(2-piperidinoethylamino)acetylaminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

4,4-dimethyl-1-<4'-(N-ethoxycarbonylpiperazinylacetyl)aminophenyl>-1,4-dihydro-3(2H)-isoquinolinone

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