1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

Base Information

Chemical Name:1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-
CAS No.:918440-14-9
Molecular Formula:C13H18BrIN2OSi
Molecular Weight:453.193
Hs Code.:
Mol file:918440-14-9.mol

Synonyms:5-bromo-3-iodo-1-[2-(trimethylsilanyl)ethoxymethyl]-1H-indazole;1H-Indazole,5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl];

Suppliers and Price of 1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
5-bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole 95%
1g
$ 1018.00

Alichem
5-Bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole
1g
$ 901.25

A1 Biochem Labs
5-Bromo-3-iodo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazole 95%
2.5 g
$ 1100.00

Total 8 raw suppliers

Chemical Property of 1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

Chemical Property:

Boiling Point:431.0±40.0 °C(Predicted)
PKA:-1.04±0.50(Predicted)
PSA：27.05000
Density:1.65±0.1 g/cm3(Predicted)
LogP:4.71570

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

There total 4 articles about 1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 459133-66-5
5-bromo-3-iodo-1H-indazole

: 918440-14-9
5-bromo-3-iodo-1-[2-(trimethylsilanyl)ethoxymethyl]-1H-indazole

Guidance literature:: With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1055/s-2006-950242

Reference yield:

: 459133-66-5
5-bromo-3-iodo-1H-indazole

: 918440-14-9
5-bromo-3-iodo-1-[2-(trimethylsilanyl)ethoxymethyl]-1H-indazole

: 1012104-27-6
5-bromo-3-iodo-2-(2-trimethylsilanyl-ethoxymethyl)-1H-indazole

Guidance literature:: 5-bromo-3-iodo-1H-indazole; With sodium hydride; In tetrahydrofuran; at 0 ℃;

With (2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 918440-14-9
5-bromo-3-iodo-1-[2-(trimethylsilanyl)ethoxymethyl]-1H-indazole

: 1012104-27-6
5-bromo-3-iodo-2-(2-trimethylsilanyl-ethoxymethyl)-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

With iodine; sodium hydride; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;