5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

Base Information

Chemical Name:5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine
CAS No.:160905-64-6
Molecular Formula:C₆₂H₆₅FN₆O₇Si
Molecular Weight:1053.32
Hs Code.:

Synonyms:5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

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Chemical Property of 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

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Technology Process of 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

There total 8 articles about 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

: 42506-03-6
pixyl chloride

: 160905-67-9
5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyladenosine

: 160905-64-6
5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

Guidance literature:: With pyridine; Ambient temperature;

Reference yield:

: 69304-45-6
3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

: 160905-64-6
5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pyridine / 1) 30 min, room temperature; 2) 90 min, room temperature

2: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

3: 86.3 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

4: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.13 h / Ambient temperature

5: 84.2 percent / imidazole / dimethylformamide / Ambient temperature

6: 97.4 percent / pyridine / Ambient temperature

With pyridine; 1H-imidazole; mesitylene sulfonic acid; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 160905-64-6
5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pyridine / 1) 30 min, room temperature; 2) 90 min, room temperature

2: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

3: 86.3 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

4: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.13 h / Ambient temperature

5: 84.2 percent / imidazole / dimethylformamide / Ambient temperature

6: 97.4 percent / pyridine / Ambient temperature

With pyridine; 1H-imidazole; mesitylene sulfonic acid; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;