6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile
• CAS No.: 1027605-97-5
• Molecular Formula: C₁₃H₆Cl₂N₄S
• Molecular Weight: 321.189
• Mol file: 1027605-97-5.mol

Synonyms:6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile

Chemical Property of 6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile

There total 2 articles about 6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2,3-dichlorophenyl)methylene]propanedinitrile (348152-30-7) + Cyanothioacetamide (7357-70-2) → 6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile (1027605-97-5)

Guidance literature:

With piperidine; In ethanol; at 80 ℃; for 5h;

DOI:10.1021/jm061045z

Reference yield:

2,3-dichlorobenzylaldehyde (6334-18-5) → 6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile (1027605-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: β-alanine / ethanol / 72 h / 20 °C

2: piperidine / ethanol / 5 h / 80 °C

With piperidine; 3-amino propanoic acid; In ethanol; 1: Knoevenagel condensation;

DOI:10.1021/jm061045z

Reference yield:

6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile (1027605-97-5) → 2-amino-4-(2,3-dichloro-phenyl)-6-(2-diethylamino-ethylsulfanyl)-pyridine-3,5-dicarbonitrile

Guidance literature:

6-amino-4-(2,3-dichloro-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.0166667h;

2-(N,N-diethylamino)ethyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/jm061045z

upstream raw materials:

2-[(2,3-dichlorophenyl)methylene]propanedinitrile

Cyanothioacetamide

2,3-dichlorobenzylaldehyde