C₄₀H₄₁N₃O₁₃

Base Information

• Chemical Name: C₄₀H₄₁N₃O₁₃
• CAS No.: 928838-76-0
• Molecular Formula: C₄₀H₄₁N₃O₁₃
• Molecular Weight: 771.778
• Mol file: 928838-76-0.mol

Synonyms:C₄₀H₄₁N₃O₁₃

Chemical Property of C₄₀H₄₁N₃O₁₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₀H₄₁N₃O₁₃

There total 5 articles about C₄₀H₄₁N₃O₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

doxorubicin (23214-92-8) + C15H18N2O3 (928838-79-3) → C40H41N3O13 (928838-76-0)

Guidance literature:

C₁₅H₁₈N₂O₃; With water; lithium hydroxide; In tetrahydrofuran; at 23 ℃; for 12h;

doxorubicin; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 23 ℃; for 12h;

Reference yield:

4-Carboxybenzaldehyde (619-66-9) → C40H41N3O13 (928838-76-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 36 h / Reflux

2.1: hydrogenchloride / water / 24 h / Reflux

3.1: acetyl chloride; thionyl chloride / 1 h / Inert atmosphere; Reflux

4.1: sodium hydride / tetrahydrofuran / 1 h

4.2: 12 h / 23 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 23 °C

5.2: 12 h / 23 °C

With hydrogenchloride; thionyl chloride; water; sodium hydride; acetyl chloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

C12H15ClO3 (928838-78-2) → C40H41N3O13 (928838-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

1.2: 12 h / 23 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 23 °C

2.2: 12 h / 23 °C

With water; sodium hydride; lithium hydroxide; In tetrahydrofuran;

upstream raw materials:

p-ethoxycarbonylbenzaldehyde

4-Carboxybenzaldehyde

doxorubicin

C₁₅H₁₈N₂O₃

Downstream raw materials:

1H-imidazole

ethanol

N-(4-formylbenzoyl)doxorubicin