2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Base Information

Chemical Name:2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline
CAS No.:1446863-05-3
Molecular Formula:C₂₇H₂₇N₃O₂
Molecular Weight:425.53
Hs Code.:

Synonyms:2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Suppliers and Price of 2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

There total 9 articles about 2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1446863-01-9
2-[[1,1'-biphenyl-5-(carboxy)-4’-(t-butyl)]-3-yl]quinoxaline

: 141-43-5
ethanolamine

: 1446863-05-3
2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Guidance literature:: 2-[[1,1'-biphenyl-5-(carboxy)-4’-(t-butyl)]-3-yl]quinoxaline; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

ethanolamine; With triethylamine; In dichloromethane; at -78 - 20 ℃; for 1h;

Reference yield:

: 2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

: 141-43-5
ethanolamine

: 1446863-05-3
2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Guidance literature:: With triethylamine; In dichloromethane; at 17 - 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.06.048

Reference yield:

: 188813-07-2
methyl 3-bromo-5-iodobenzoate

: 1446863-05-3
2-[[1,1'-biphenyl-5-(N-(2-hydroxyethyl)aminocarboxy)-4’-(t-butyl)]-3-yl]quinoxaline

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

6: triethylamine / dichloromethane / 1 h / 17 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; lithium hydroxide monohydrate; potassium acetate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.06.048