(E)-N-(2-chlorophenyl)-N,N-dimethylformamidine

Base Information

• Chemical Name: (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine
• CAS No.: 74739-48-3
• Molecular Formula: C₉H₁₁ClN₂
• Molecular Weight: 182.653
• Mol file: 74739-48-3.mol

Synonyms:(E)-N-(2-chlorophenyl)-N,N-dimethylformamidine

Chemical Property of (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine

There total 2 articles about (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-2-isocyanobenzene (10432-84-5) → (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine (74739-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: AgCl / -15 °C

2: CHCl₃ / 6 h / Heating

silver(I) chloride; In chloroform;

DOI:10.1016/S0040-4039(00)71534-6

Reference yield:

N,N-dimethyl-N'-(2-chlorophenyl)formamidine (74407-98-0) → (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine (74739-48-3)

Guidance literature:

In chloroform; for 6h; Heating;

DOI:10.1016/S0040-4039(00)71534-6

Reference yield: 90.7%

(E)-N-(2-chlorophenyl)-N,N-dimethylformamidine (74739-48-3) + 4-methoxy-benzylamine (2393-23-9) → 1-(4-methoxybenzyl)-1H-benzo[d]imidazole (46885-71-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; potassium hydroxide; In toluene; at 90 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Sealed tube;

upstream raw materials:

N,N-dimethyl-N'-(2-chlorophenyl)formamidine

1-chloro-2-isocyanobenzene

Downstream raw materials:

1-(4-methoxybenzyl)-1H-benzo[d]imidazole