6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine

Base Information

• Chemical Name: 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine
• CAS No.: 131194-06-4
• Molecular Formula: C₂₁H₃₀N₂O₅Si
• Molecular Weight: 418.565
• Mol file: 131194-06-4.mol

Synonyms:6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine

Chemical Property of 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine

There total 3 articles about 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[(2-hydroxyethoxy)methyl]thymine (68724-11-8) → 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine (131194-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h

With 1H-imidazole; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00105a055

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine (131194-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h

With 1H-imidazole; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00105a055

Reference yield:

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine (121749-98-2) + benzoyl chloride (98-88-4) → 6-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine (131194-06-4)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h;

DOI:10.1021/jm00105a055

upstream raw materials:

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine

benzoyl chloride

1-[(2-hydroxyethoxy)methyl]thymine

tert-butyldimethylsilyl chloride

Downstream raw materials:

6-Benzoyl-1-(2-hydroxy-ethoxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(1-hydroxy-1-phenylmethyl)thymine

6-benzyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>thymine

1-[(2-hydroxyethoxy)methyl]-6-benzylthymine