(3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

Base Information

Chemical Name:(3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester
CAS No.:116627-55-5
Molecular Formula:C₂₄H₃₄O₄Si
Molecular Weight:414.617
Hs Code.:

Synonyms:(3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

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Chemical Property of (3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

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Technology Process of (3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

There total 7 articles about (3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 116627-55-5
(3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / HCl gas / 0 °C

2: 91 percent / H₂ / Raney-Ni / propan-1-ol; triethylamine / 25 °C

3: H₂O / pig liver esterase (PLE) / 30 h / 0 °C / pH 7 (0.3 M aqueous KH₂PO₄ and 1N NaOH)

4: imidazol / CH₂Cl₂ / 0 °C

5: H₂O, Na₂CO₃ / 25 °C

6: BF₃-THF / 6 h / -20 - 0 °C

With 1H-imidazole; hydrogenchloride; boron trifluoride-tetrahydrofuran complex; water; hydrogen; sodium carbonate; pig liver esterase; nickel; In propan-1-ol; dichloromethane; triethylamine;
DOI:10.1016/S0040-4039(00)86112-2

Reference yield:

: 116627-53-3
3-Hydroxy-pentanedioic acid dipropyl ester

: 116627-55-5
(3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂O / pig liver esterase (PLE) / 30 h / 0 °C / pH 7 (0.3 M aqueous KH₂PO₄ and 1N NaOH)

2: imidazol / CH₂Cl₂ / 0 °C

3: H₂O, Na₂CO₃ / 25 °C

4: BF₃-THF / 6 h / -20 - 0 °C

With 1H-imidazole; boron trifluoride-tetrahydrofuran complex; water; sodium carbonate; pig liver esterase; In dichloromethane;
DOI:10.1016/S0040-4039(00)86112-2

Reference yield:

: 53630-64-1
dipropyl 1,3-acetonedicarboxylate

: 116627-55-5
(3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / H₂ / Raney-Ni / propan-1-ol; triethylamine / 25 °C

2: H₂O / pig liver esterase (PLE) / 30 h / 0 °C / pH 7 (0.3 M aqueous KH₂PO₄ and 1N NaOH)

3: imidazol / CH₂Cl₂ / 0 °C

4: H₂O, Na₂CO₃ / 25 °C

5: BF₃-THF / 6 h / -20 - 0 °C

With 1H-imidazole; boron trifluoride-tetrahydrofuran complex; water; hydrogen; sodium carbonate; pig liver esterase; nickel; In propan-1-ol; dichloromethane; triethylamine;
DOI:10.1016/S0040-4039(00)86112-2