methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester
CAS No.:735270-19-6
Molecular Formula:C₂₂H₃₄O₇S
Molecular Weight:442.574
Hs Code.:

Synonyms:methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

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Chemical Property of methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

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Technology Process of methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

There total 7 articles about methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 124-63-0
methanesulfonyl chloride

: 735270-05-0
2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethanol

: 735270-19-6
methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2004.05.021

Reference yield:

: 61330-09-4
dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate

: 735270-19-6
methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 89 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Heating

2.1: 87 percent / NaCl; H₂O / dimethylsulfoxide / 6 h / 140 °C

3.1: 95 percent / PPTS / benzene / 3 h / Heating

4.1: 100 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

5.1: 82 percent / NaNH₂ / diethyl ether; tetrahydrofuran / 0.17 h / 0 °C

6.1: BH₃*Me₂S / tetrahydrofuran / 0 °C

6.2: 75 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O

7.1: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With dimethylsulfide borane complex; water; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; sodium amide; triethylamine; sodium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene; 1.1: Dieckmann condensation / 2.1: Krapcho's demethoxycarbonylation / 5.1: Wittig reaction;
DOI:10.1016/j.tetlet.2004.05.021

Reference yield:

: 51533-65-4
4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone

: 735270-19-6
methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / PPTS / benzene / 3 h / Heating

2.1: 100 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 82 percent / NaNH₂ / diethyl ether; tetrahydrofuran / 0.17 h / 0 °C

4.1: BH₃*Me₂S / tetrahydrofuran / 0 °C

4.2: 75 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O

5.1: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With dimethylsulfide borane complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium amide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 3.1: Wittig reaction;
DOI:10.1016/j.tetlet.2004.05.021