Technology Process of methyl 1α-(benzyloxy)-8-bromo-6β-(3'-hydroxyprop-2'-en-1'-yl)-5α-methyl-1,2,3,4aβ,5,6,8aα-octahydronaphthalene-5β-carboxylate
There total 14 articles about methyl 1α-(benzyloxy)-8-bromo-6β-(3'-hydroxyprop-2'-en-1'-yl)-5α-methyl-1,2,3,4aβ,5,6,8aα-octahydronaphthalene-5β-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) MsCl, Et3N / 2.) Bu4NI / 1.) 0 deg C, 2.) DMF, 80 deg C
2: 1.) CH3COOH, CH3OH, 2.) NaIO4 / 1.) reflux 2.) THF, H2O
4: 67 percent / LDA / tetrahydrofuran / -78 - 23 °C
5: 1.) DIBAL-H / 1.) toluene, -78 deg C, 2.) CH2Cl2, RT
With
methanol; sodium periodate; diisobutylaluminium hydride; acetic acid; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)98725-2
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) BH3 2.) 3M NaOH, 30 percent H2O2 / 1.) THF, 0 deg C
2: 1.) MsCl, Et3N / 2.) Bu4NI / 1.) 0 deg C, 2.) DMF, 80 deg C
3: 1.) CH3COOH, CH3OH, 2.) NaIO4 / 1.) reflux 2.) THF, H2O
5: 67 percent / LDA / tetrahydrofuran / -78 - 23 °C
6: 1.) DIBAL-H / 1.) toluene, -78 deg C, 2.) CH2Cl2, RT
With
methanol; sodium hydroxide; sodium periodate; borane; dihydrogen peroxide; diisobutylaluminium hydride; acetic acid; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)98725-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 2.) NaH / 1.) CH2Cl2, -78 deg C 2.) THF, DMF, reflux
2: 1.) BH3 2.) 3M NaOH, 30 percent H2O2 / 1.) THF, 0 deg C
3: 1.) MsCl, Et3N / 2.) Bu4NI / 1.) 0 deg C, 2.) DMF, 80 deg C
4: 1.) CH3COOH, CH3OH, 2.) NaIO4 / 1.) reflux 2.) THF, H2O
6: 67 percent / LDA / tetrahydrofuran / -78 - 23 °C
7: 1.) DIBAL-H / 1.) toluene, -78 deg C, 2.) CH2Cl2, RT
With
methanol; sodium hydroxide; sodium periodate; borane; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; acetic acid; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)98725-2
