1-[4-(3-Chlorophenoxy)phenyl]ethanone

Base Information

• Chemical Name: 1-[4-(3-Chlorophenoxy)phenyl]ethanone
• CAS No.: 1145-57-9
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.693
• DSSTox Substance ID: DTXSID601285863
• Mol file: 1145-57-9.mol

Synonyms:1-[4-(3-Chlorophenoxy)phenyl]ethanone;1145-57-9;Ethanone, 1-[4-(3-chlorophenoxy)phenyl]-;SCHEMBL2775115;DTXSID601285863;AKOS000219672;A1-05676

Chemical Property of 1-[4-(3-Chlorophenoxy)phenyl]ethanone

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 246.0447573
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)OC2=CC(=CC=C2)Cl

Technology Process of 1-[4-(3-Chlorophenoxy)phenyl]ethanone

There total 6 articles about 1-[4-(3-Chlorophenoxy)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-monochlorophenol (108-43-0) + 1-(4-fluorophenyl)ethanone (403-42-9) → 3-chlorophenyl 4-acetylphenyl ether (1145-57-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; Heating;

DOI:10.1016/j.bmc.2003.12.003

Reference yield: 82.0%

→ 3-chlorophenyl 4-acetylphenyl ether (1145-57-9)

Guidance literature:

Reference yield:

3-monochlorophenol (108-43-0) + para-bromoacetophenone (99-90-1) → 3-chlorophenyl 4-acetylphenyl ether (1145-57-9)

Guidance literature:

With potassium carbonate; copper; copper(I) bromide; at 200 ℃;

upstream raw materials:

para-bromoacetophenone

sodium m-chlorophenoxide

1-chloro-3-phenoxybenzene

acetyl chloride

Downstream raw materials:

4-(3-chlorophenoxy)benzoic acid

3-chlorophenyl 4-(hydroxyisopropyl)phenyl ether

3-chlorophenyl 4-(chloroisopropyl)phenyl ether

4-<3-Chlor-4-butyryl-phenoxy>-benzoesaeure-methylester