N-(β-hydroxyethyl)-o-bromobenzamide

Base Information

Chemical Name:N-(β-hydroxyethyl)-o-bromobenzamide
CAS No.:82891-94-9
Molecular Formula:C₉H₁₀BrNO₂
Molecular Weight:244.088
Hs Code.:

Synonyms:N-(β-hydroxyethyl)-o-bromobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(β-hydroxyethyl)-o-bromobenzamide

Chemical Property:

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Technology Process of N-(β-hydroxyethyl)-o-bromobenzamide

There total 3 articles about N-(β-hydroxyethyl)-o-bromobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 141-43-5
ethanolamine

: 82891-94-9
N-(β-hydroxyethyl)-o-bromobenzamide

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In acetonitrile; at 20 ℃; for 15h; Schlenk technique; Inert atmosphere;
DOI:10.1021/jo501929c

Reference yield: 94.0%

: 141-43-5
ethanolamine

: 7154-66-7
2-bromobenzoic acid chloride

: 82891-94-9
N-(β-hydroxyethyl)-o-bromobenzamide

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h;
DOI:10.1016/j.tet.2017.02.025

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 82891-94-9
N-(β-hydroxyethyl)-o-bromobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 15 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1021/acs.joc.9b01536