(Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione

Base Information

• Chemical Name: (Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione
• CAS No.: 1432595-85-1
• Molecular Formula: C₁₆H₁₃BrO₂S
• Molecular Weight: 349.248

Synonyms:(Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione

Chemical Property of (Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione

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Technology Process of (Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione

There total 1 articles about (Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl (4-methoxyphenyl)carbodithioate (5874-09-9) + 1-(3-Bromophenyl)ethanone (2142-63-4) → (Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione (1432595-85-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo400599e

Reference yield: 86.0%

(Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione (1432595-85-1) + phenylhydrazine (100-63-0) → 5-(3-bromophenyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole (1432595-97-5)

Guidance literature:

In ethanol; for 4h; regioselective reaction; Reflux;

DOI:10.1021/jo400599e

Reference yield:

(Z)-3-(3-bromophenyl)-3-hydroxy-1-(4-methoxyphenyl)prop-2-ene-1-thione (1432595-85-1) + methyl iodide (74-88-4) → (Z)-1-(3-bromophenyl)-3-(4-methoxyphenyl)-3-(methylthio)-prop-2-en-1-one (1432596-08-1) + (E)-1-(3-bromophenyl)-3-(4-methoxyphenyl)-3-(methylthio)-prop-2-en-1-one (1432596-21-8)

Guidance literature:

at 0 - 20 ℃; for 4h; Overall yield = 67 %; Overall yield = 0.24 g;

DOI:10.1021/jo400599e

upstream raw materials:

methyl (4-methoxyphenyl)carbodithioate

1-(3-Bromophenyl)ethanone

Downstream raw materials:

5-(3-bromophenyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole

(Z)-1-(3-bromophenyl)-3-(4-methoxyphenyl)-3-(methylthio)-prop-2-en-1-one

(E)-1-(3-bromophenyl)-3-(4-methoxyphenyl)-3-(methylthio)-prop-2-en-1-one

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