2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Base Information

Chemical Name:2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine
CAS No.:1399035-84-7
Molecular Formula:C₁₉H₁₈F₄N₄
Molecular Weight:378.372
Hs Code.:

Synonyms:2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

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Chemical Property of 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

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Technology Process of 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

There total 7 articles about 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1399035-82-5
4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine acetic acid salt

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1399035-84-7
2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Guidance literature:: 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine acetic acid salt; With potassium hydroxide; In tetrahydrofuran; at 30 - 40 ℃; for 1h;

(2-chloroethyl)dimethylamine hydrochloride; In tetrahydrofuran; at 60 - 65 ℃; for 20h;
DOI:10.1055/s-0031-1290371

Reference yield:

: 1399035-82-5
4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine acetic acid salt

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1399035-84-7
2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

: 1399035-85-8
2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridine-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 63 - 65 ℃; for 18h;
DOI:10.1055/s-0031-1290371

Reference yield:

: 1082951-17-4
(2-amino-1-(4-fluoro, 3-trifluoromethyl-phenyl)-ethanone) p-toluenesulfonate

: 1399035-84-7
2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.5 h / 25 °C

2.1: acetic acid / 20 h / 140 °C

3.1: potassium hydroxide / tetrahydrofuran / 1 h / 30 - 40 °C

3.2: 20 h / 60 - 65 °C

With triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1055/s-0031-1290371