[(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

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Chemical Name:[(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol
CAS No.:1352743-39-5
Molecular Formula:C₃₇H₄₆N₂O₃Si
Molecular Weight:594.869
Hs Code.:

Synonyms:[(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

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Chemical Property of [(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

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Technology Process of [(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

There total 10 articles about [(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 22348-32-9,63401-04-7,112022-88-5,112068-01-6
(S)-diphenylprolinol

: 1352743-37-3
(R)-2-(bromomethyl)-6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridine

: 1352743-39-5
[(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

Guidance literature:: With potassium carbonate; In ethanol; at 20 ℃; for 72h;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

: 1352743-39-5
[(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

Guidance literature:: Multi-step reaction with 7 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

4: 2 h / 90 °C

5: potassium carbonate / methanol / 6 h / 20 °C

6: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 20 °C

7: potassium carbonate / ethanol / 72 h / 20 °C

With carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 4: Boekelheide rearrangement;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-21-5
(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

: 1352743-39-5
[(S)-1-({6-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl)pyrrolidin-2-yl]diphenylmethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2: 2 h / 90 °C

3: potassium carbonate / methanol / 6 h / 20 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 20 °C

5: potassium carbonate / ethanol / 72 h / 20 °C

With carbon tetrabromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In methanol; ethanol; dichloromethane; 2: Boekelheide rearrangement;
DOI:10.1002/ejoc.201100681