(R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

Base Information

Chemical Name:(R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide
CAS No.:1351610-74-6
Molecular Formula:C₂₀H₂₉NO₃Si
Molecular Weight:359.541
Hs Code.:

Synonyms:(R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

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Chemical Property of (R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

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Technology Process of (R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

There total 6 articles about (R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1352743-21-5
(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

: 1351610-74-6
(R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

: 1351610-74-6
(R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-15-7
(R)-2-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-6-methylpyridin-4(1H)-one

: 1351610-74-6
(R)-2-[(tert-butyldimethylsilyloxy)-(phenyl)methyl]-4-methoxy-6-methylpyridine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100681