methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

Base Information

Chemical Name:methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate
CAS No.:1186017-07-1
Molecular Formula:C₃₀H₄₂N₂O₇S
Molecular Weight:574.739
Hs Code.:

Synonyms:methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

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Chemical Property of methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

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Technology Process of methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

There total 3 articles about methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-78-1
methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propionate

: 74-88-4
methyl iodide

: 1186017-07-1
methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

Guidance literature:: methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propionate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.16667h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 959937-79-2
3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propionic acid

: 1186017-07-1
methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; hexane / 20 h / 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C

2.2: 1 h / -78 °C

With sodium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane;

Reference yield:

: 959937-80-5
3-[(2R,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionitrile

: 1186017-07-1
methyl (R,S)-3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / ethanol / 21 h / 80 °C

1.2: pH 2 - 3

2.1: methanol; hexane / 20 h / 0 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C

3.2: 1 h / -78 °C

With water; sodium hexamethyldisilazane; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane;