2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate

Base Information

• Chemical Name: 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate
• CAS No.: 1262048-26-9
• Molecular Formula: C₁₃H₁₉ClN₂O₃S
• Molecular Weight: 318.824
• Mol file: 1262048-26-9.mol

Synonyms:2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate

Chemical Property of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate

There total 2 articles about 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-(4-(4-chlorophenyl)piperazin-1-yl)ethanol (55179-20-9) + methanesulfonyl chloride (124-63-0) → 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate (1262048-26-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1590/S0103-50532010000100011

Reference yield:

4-(4-chlorophenyl) piperazine (38212-33-8) → 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate (1262048-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 °C

2: dichloromethane / 2 h / Alkaline conditions; Reflux

With potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2018.06.019

Reference yield: 35.0%

2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate (1262048-26-9) + 2-(3-pyridyl)-1H-benzimidazole (1137-67-3) → 1-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-2-pyridin-3-yl-1H-benzimidazole (1262048-36-1)

Guidance literature:

2-(3-pyridyl)-1H-benzimidazole; With sodium hydroxide; In acetonitrile; for 2h;

2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl methanesulfonate; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1590/S0103-50532010000100011

upstream raw materials:

2-(4-(4-chlorophenyl)piperazin-1-yl)ethanol

methanesulfonyl chloride

4-(4-chlorophenyl) piperazine

Downstream raw materials:

1-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-2-pyridin-3-yl-1H-benzimidazole