1137-67-3Relevant academic research and scientific papers
Syntheses, structures, and properties of transition metal complexes with 2-(n-pyridyl)benzimidazole (n=2, 3, and 4)
Zhou, Ying-Xia,Li, Xia,Zhaang, Hai-Yan,Fan, Cai-Ling,Zhang, Hong-Yun,Wu, Ben-Lai
, p. 4066 - 4078 (2011)
Three pyridylbenzimidazoles (2-PBIM, 3-PBIM, and 4-PBIM) have been prepared (2-PBIM: 2-(2-pyridyl)-benzimidazole, 3-PBIM: 2-(3-pyridyl)-benzimidazole, 4-PBIM: 2-(4-pyridyl)-benzimidazole). Reactions of several transition metals (Cd2+, Cu2+, Fe2+) with the three ligands gave four new coordination complexes, [(Cd)2(2-PBIM)2(CH 3COO)4] (1), [Cu(3-PBIM)2 (CH 3COO)2] · 2H2O (2), [Cu(4-PBIM) 2(CH3COO)2(H2O)] · H 2O (3), and [Fe(4-PBIM)2 (Cl)2(H 2O)2] (4), respectively. These four complexes have been characterized by X-ray crystallography, IR spectroscopy, and UV absorption spectroscopy. Thermogravimetric properties of 2 and 4 were also measured. X-ray crystallographic studies reveal that these four complexes are very different, although the ligands are similar in structure. The role of hydrogen-bonding and π-π interactions in extending dimensionality of simple complexes has been discussed.
Electrochemical Synthesis of Benzazoles from Alcohols and o-Substituted Anilines with a Catalytic Amount of CoII Salt
Lai, Yin-Long,Ye, Jian-Shan,Huang, Jing-Mei
, p. 5425 - 5429 (2016)
An electrochemical synthesis of benzazoles directly from alcohols and o-substituted anilines has been developed. The reaction conditions have been optimized by varying the composition of the electrolyte and the metal salt used as catalyst. The cyclization proceeds smoothly with a catalytic amount of a cobalt salt under air at room temperature to afford 2-substituted benzimidazoles, benzothiazoles, and benzoxazoles in good to excellent yields with a wide substrate scope.
Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles - A new family of high affinity CB1 cannabinoid ligands
Mella-Raipan, Jaime A.,Lagos, Carlos F.,Recabarren-Gajardo, Gonzalo,Espinosa-Bustos, Christian,Romero-Parra, Javier,Pessoa-Mahana, Hernan,Iturriaga-Vasquez, Patricio,Pessoa-Mahana, Carlos David
, p. 3972 - 4001 (2013)
A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinities with Ki values in the nanomolar range. JM-39 (compound 39) was the most active of the series (KiCB1 = 0.53 nM), while compounds 31 and 44 exhibited similar affinities to WIN 55212-2. CoMFA analysis was performed based on the biological data obtained and resulted in a statistically significant CoMFA model with high predictive value (q2 = 0.710, r2 = 0.998, r2pred = 0.823).
Synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)benzimidazoles
Jung, Myung Hee,Park, Jung Mee,Lee, Ihl-Young Choi,Ahn, Mija
, p. 37 - 44 (2003)
A useful approach for the synthesis of pharmacologically active tetrahydropyridinylbenzimidazoles is described. 2-Pyridin-3-ylbenzimidazoles 3a-d have been synthesized by condensation of 3-pyridinecarboxaldehyde 1 with substituted 1,2-phenylenediamines 2a-d following oxidative cyclization with iodobenzene diacetate. Methylation of 3a-d with iodomethane and potassium hydroxide, subsequent formation of methylpyridinium salts 4a-d and 7a-d and reduction thereafter afforded tetrahydropyridinylbenzimidazoles 5a-d and 8a-d.
Structural and luminescent properties of a series of Cd(II) pyridyl benzimidazole complexes that exhibit extended three-dimensional hydrogen bonded networks
Wang, Jin-Hua,Tang, Gui-Mei,Qin, Ting-Xiao,Wang, Yong-Tao,Cui, Yue-Zhi,Ng, Seik?Weng
, p. 1168 - 1189 (2017)
Five new coordination complexes, [CdI2(3-PyBim)](H2O)3 (1), [Cd(SO4)(3-PyBim)(H2O)4] (2), [CdCl2(4-PyBim)2(H2O)2] (3), [CdBr2(4-PyBim)2(H2O)2] (4) and [CdI2(4-PyBim)2(H2O)2] (5) [3-PyBim=2-Pyridin-3-yl-1H-benzoimidazole, 4-PyBim=2-Pyridin-4-yl-1H-benzoimidazole], were obtained under hydrothermal conditions and characterized by single crystal X-ray diffraction, IR, elemental analysis, and powder X-ray diffraction. All of the complexes have mononuclear structures. Among the crystal structures of these complexes, there exist a variety of intermolecular hydrogen bonding interactions and π?π interactions, which further extend to a 3-D supramolecular architecture. The solid state photoluminescent properties of 1–5 vary with the electronegativity of the coordination anion. Additionally, the thermogravimetric analyses of these complexes are discussed.
Acceptorless dehydrogenative synthesis of benzothiazoles and benzimidazoles from alcohols or aldehydes by heterogeneous Pt catalysts under neutral conditions
Chaudhari, Chandan,Siddiki, S.M.A. Hakim,Shimizu, Ken-Ichi
, p. 4885 - 4888 (2015)
Abstract Pt/Al2O3 and Pt/TiO2 were effective catalysts for the synthesis of 2-substituted benzothiazoles and benzimidazoles from 2-aminothiophenol and 1,2-phenylenediamine with alcohols or aldehydes under acceptor-free and additive-free conditions.
Two new silver(I) ammine complexes by displacement reaction between [Ag(NH3)2]+ ions and different pyridine-4,5-Imidazoledicarboxylic Acids
Zhou, Rui-Sha,Song, Jiang-Feng,Li, Yan-Bin,Xu, Chun-Yan,Yang, Xiao-Feng
, p. 251 - 256 (2011)
[Ag(NH3)2]+ ions are chosen as an initial reaction precursor because of its simple displacement reaction and intrinsic arrangement as well as specific coordination directionality. Two new silver(I) ammine complexes, Ag2(NH3)HL2 (2) and Ag 2(NH3)2HL3 (3), were obtained by a simple substitution reaction between [Ag(NH3)2] + ions and pyridine-4,5-imidazoledicarboxylic acid [H 3L2 = 2-(3′-pyridyl) 4,5-imidazoledicarboxylic acid and H3L3 = 2-(4′-pyridyl) 4,5-imidazoledicarboxylic acid]. Silver dimers are connected into a 2D layer and 1D chain in complexes 2 and 3, respectively. In complex 2 two kinds of displacement reactions (mono-substituting and bis-substituting) occurred between the ammine molecules in [Ag(NH3)2]+ ions and H3L 2, however, only the mono-substituting reaction occurs in complex 3.
Microwave-assisted synthesis of aryl and heteroaryl derivatives of benzimidazole
Yu, Haitao,Kawanishi, Hirohisa,Koshima, Hideko
, p. 1457 - 1460 (2003)
A series of benzimidazoles containing aryl and heteroaryl substituents were efficiently and quickly synthesized by condensation of 1,2phenylenediamine with carboxylic acids in the presence of polyphosphoric acid under microwave irradiation.
Thermal and Spectral Studies of Peroxo Complexes of Molybdenum(VI) and Tungsten(VI) with Benzimidazole Derivatives
Maurya, Mannar R.,Jayaswal, Mathuresh N.
, p. 446 - 447 (1998)
Synthesis, spectral and thermal studies of diperoxo complexes of molybdenum(VI) and tungsten(VI) with 2-(2-pyridyl)-benzimidazole, 2-(3-pyridyl)benzimidazole and 2,6-bis(benzimidazol-2-yl)pyridine are reported.
Sonicated assisted synthesis of benzimidazoles, benzoxazoles and benzothiazoles in aqueous media
Pardeshi, Sandeep D.,Sonar, Jayant P.,Pawar, Shivaji S.,Dekhane, Deepak,Gupta, Sunil,Zine, Ashok M.,Thore, Shivaji N.
, p. 2335 - 2340 (2014)
Ammonium nickel sulphate [(NH4)2SO4.NiSO4.6H2O] was found as a new catalyst to synthesis 2-aryl benzimidazole, 2-aryl benzothiazole and 2-aryl benzoxazole in aqueous media under sonication irradiation. The procedure is an eco-friendly, efficient and provides simple workup and good yield.
