[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

Base Information

Chemical Name:[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide
CAS No.:181697-13-2
Molecular Formula:C₂₂H₁₉N₃O₄S
Molecular Weight:421.477
Hs Code.:

Synonyms:[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

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Chemical Property of [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

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Technology Process of [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

There total 7 articles about [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 181697-12-1
methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

: 181697-13-2
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

Guidance literature:: With ammonia; In tetrahydrofuran; ethanol; at 5 - 20 ℃; for 60.33h; under 1189.47 Torr;

Reference yield:

: 451-40-1
phenyl benzyl ketone

: 181697-13-2
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: chlorosulfonic acid / 14 h / 5 - 20 °C

2.1: ammonia / water; acetone

3.1: thionyl chloride / ethanol / 0.5 h / Heating / reflux

4.1: hydroxylamine hydrochloride; sodium acetate / 14 h / Heating / reflux

5.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.17 h / -78 - 0 °C

5.2: 2 h / -25 - 20 °C

6.1: trifluoroacetic acid / water / 11 h / 50 °C / Heating / reflux

6.2: 2 h / Heating / reflux

7.1: ammonia / tetrahydrofuran; ethanol / 60.33 h / 5 - 20 °C / 1189.47 Torr

With chlorosulfonic acid; thionyl chloride; hydroxylamine hydrochloride; ammonia; sodium acetate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; water; acetone;

Reference yield:

: 2,5-dimethyl-1-[[4-(2-oxo-2-phenylethyl)phenyl]sulfonyl]-1H-pyrrole

: 181697-13-2
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / 14 h / Heating / reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.17 h / -78 - 0 °C

2.2: 2 h / -25 - 20 °C

3.1: trifluoroacetic acid / water / 11 h / 50 °C / Heating / reflux

3.2: 2 h / Heating / reflux

4.1: ammonia / tetrahydrofuran; ethanol / 60.33 h / 5 - 20 °C / 1189.47 Torr

With hydroxylamine hydrochloride; ammonia; sodium acetate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; water;