methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

Base Information

Chemical Name:methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate
CAS No.:181697-12-1
Molecular Formula:C₂₃H₂₀N₂O₅S
Molecular Weight:436.488
Hs Code.:

Synonyms:methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

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Chemical Property of methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

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Technology Process of methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

There total 6 articles about methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 67-56-1
methanol

: 181697-11-0
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylic acid

: 181697-12-1
methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

Guidance literature:: [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylic acid; With trifluoroacetic acid; In water; at 50 ℃; for 11h; Heating / reflux;

methanol; With thionyl chloride; for 2h; Heating / reflux;

Reference yield:

: 451-40-1
phenyl benzyl ketone

: 181697-12-1
methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: chlorosulfonic acid / 14 h / 5 - 20 °C

2.1: ammonia / water; acetone

3.1: thionyl chloride / ethanol / 0.5 h / Heating / reflux

4.1: hydroxylamine hydrochloride; sodium acetate / 14 h / Heating / reflux

5.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.17 h / -78 - 0 °C

5.2: 2 h / -25 - 20 °C

6.1: trifluoroacetic acid / water / 11 h / 50 °C / Heating / reflux

6.2: 2 h / Heating / reflux

With chlorosulfonic acid; thionyl chloride; hydroxylamine hydrochloride; ammonia; sodium acetate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; water; acetone;

Reference yield:

: 2,5-dimethyl-1-[[4-(2-oxo-2-phenylethyl)phenyl]sulfonyl]-1H-pyrrole

: 181697-12-1
methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium acetate / 14 h / Heating / reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.17 h / -78 - 0 °C

2.2: 2 h / -25 - 20 °C

3.1: trifluoroacetic acid / water / 11 h / 50 °C / Heating / reflux

3.2: 2 h / Heating / reflux

With hydroxylamine hydrochloride; sodium acetate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; water;