2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Base Information

Chemical Name:2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid
CAS No.:1033575-51-7
Molecular Formula:C₂₆H₂₁Cl₃N₂O₄
Molecular Weight:531.823
Hs Code.:

Synonyms:2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

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Chemical Property of 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

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Technology Process of 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

There total 6 articles about 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 851335-09-6
2-chloro-4-carboxybenzeneboronic acid

: 1033586-32-1
2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

: 1033575-51-7
2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Guidance literature:: With potassium carbonate; dicyclohexyl palladium acetate; In ethanol; at 80 ℃; for 4h;

Reference yield:

: 1033586-29-6
1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1033575-51-7
2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Heating / reflux; high intensity lamp

2: potassium carbonate / acetonitrile / 4 h / Heating / reflux

3: tetrahydrofuran / 1.17 h / 0 - 20 °C

4: potassium carbonate / dicyclohexyl palladium acetate / ethanol / 4 h / 80 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; dicyclohexyl palladium acetate; In tetrahydrofuran; tetrachloromethane; ethanol; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 1033586-30-9
5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1033575-51-7
2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 4 h / Heating / reflux

2: tetrahydrofuran / 1.17 h / 0 - 20 °C

3: potassium carbonate / dicyclohexyl palladium acetate / ethanol / 4 h / 80 °C

With potassium carbonate; dicyclohexyl palladium acetate; In tetrahydrofuran; ethanol; acetonitrile; 3: Suzuki Coupling;