N-methyl 2-bromo-5-pyridinecarboxamide

Base Information

• Chemical Name: N-methyl 2-bromo-5-pyridinecarboxamide
• CAS No.: 869640-48-2
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.049
• Hs Code.: 2933399090
• Mol file: 869640-48-2.mol

Synonyms:6-Bromo-N-methylnicotinamide;N-methyl 2-bromo-5-pyridinecarboxamide;N-Methyl 6-bromonicotinamide

Chemical Property of N-methyl 2-bromo-5-pyridinecarboxamide

Chemical Property:

• Boiling Point: 367.8±27.0 °C(Predicted)
• PKA: 13.85±0.46(Predicted)
• PSA: 41.99000
• Density: 1.545±0.06 g/cm3(Predicted)
• LogP: 1.59460
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-N-methylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methyl 2-bromo-5-pyridinecarboxamide

There total 2 articles about N-methyl 2-bromo-5-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

methylamine (74-89-5) → 6-bromo-N-methylnicotinamide (869640-48-2)

Guidance literature:

6-bromonicotinic acid; With 1,1'-carbonyldiimidazole; In dimethyl sulfoxide; for 24h;

methylamine; In tetrahydrofuran; dimethyl sulfoxide; for 18h;

Reference yield:

6-bromonicotinic acid (6311-35-9) + methylamine hydrochloride (593-51-1) → 6-bromo-N-methylnicotinamide (869640-48-2)

Guidance literature:

6-bromonicotinic acid; With benzotriazol-1-ol; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

methylamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

6-bromo-N-methylnicotinamide (869640-48-2) → N-(4-cyanophenyl)-N-cyclopropyl-3-(5-(methylcarbamoyl)pyridin-2-yl)pyrazolo[1,5-a]pyridine-5-carboxamide (1610611-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane;

upstream raw materials:

methylamine

6-bromonicotinic acid

methylamine hydrochloride

Downstream raw materials:

N-(4-cyanophenyl)-N-cyclopropyl-3-(5-(methylcarbamoyl)pyridin-2-yl)pyrazolo[1,5-a]pyridine-5-carboxamide