α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Base Information

Chemical Name:α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
CAS No.:94695-51-9
Molecular Formula:C₁₅H₁₃F₄NO₃
Molecular Weight:331.267
Hs Code.:

Synonyms:α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

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Technology Process of α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

There total 5 articles about α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 94714-58-6
ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

: 765-30-0
Cyclopropylamine

: 94695-51-9
α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Guidance literature:: In ethanol; for 1h; Ambient temperature;

Reference yield:

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 122-51-0
orthoformic acid triethyl ester

: 765-30-0
Cyclopropylamine

: 94695-51-9
α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Guidance literature:: With acetic anhydride; Yield given. Multistep reaction; 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght;
DOI:10.1021/jm00400a017

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 94695-51-9
α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2, DMF / CH₂Cl₂

2: tetrahydrofuran / 0.75 h / -78 °C

3: 1.) Ac₂O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght

With oxalyl dichloride; acetic anhydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00400a017