128495-48-7

Upstream product

• 128495-47-6 2-(4-fluoro-3-methoxyphenyl)nitroethylene 
• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 452-84-6 3-amino-4-fluorotoluene 
• 63762-79-8 2-fluoro-5-methylphenol 

Downstream Products

• 128495-68-1 N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 128495-66-9 N-ethyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 128495-67-0 N,N-di-n-propyl-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 128495-65-8 N-ethyl-N-n-propyl-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 128495-51-2 N-ethyl-N-(phenylacetyl)-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-54-5 N-n-propyl-N-(phenylacetyl)-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-60-3 N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-58-9 N-ethyl-N-(2-phenylethyl)-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-53-4 N-n-propyl-N-propionyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-52-3 N-n-propyl-N-acetyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-57-8 N-ethyl-N-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-59-0 N,N-di-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-56-7 N-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-55-6 N-ethyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 

Relevant academic research and scientific papers

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to generate THIAs in high yields.

TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS

The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

THERAPEUTIC COMPOUNDS

The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

Synthesis and Dopamine Receptor Affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-Substituted Derivatives

The synthesis of 2-(4-fluoro-3-hydroxyphenyl)ethylamine (26) and of some N,N-dialkyl derivatives (27-30) starting from 4-fluoro-3-hydroxytoluene and their in vitro binding affinities for dopamine (DA) receptor are reported.The amine 26 can be regarded as