5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Base Information

Chemical Name:5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone
CAS No.:175791-65-8
Molecular Formula:C₁₆H₁₄IN₃O₄
Molecular Weight:439.209
Hs Code.:

Synonyms:5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

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Chemical Property of 5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

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Technology Process of 5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

There total 12 articles about 5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 175791-64-7
2,4-Dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

: 175791-65-8
5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Guidance literature:: With potassium hydroxide; iodine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1039/p19960000459

Reference yield: 61.0%

: (5-iodo-2,4-dimethoxy-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(4-methoxyphenyl)methanone

: 175791-65-8
5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201602519

Reference yield:

: 90057-09-3
2,4-dimethoxy-7H-pyrrolo<2,3-d>pyrimidine

: 175791-65-8
5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 1 h

2: 55 percent / t-BuLi / tetrahydrofuran; pentane / 1.) -78 deg C, 0.5 h, 2.) -78 deg C, 2 h

3: 91 percent / KOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

4: 86 percent / I₂, KOH / dimethylformamide / 2 h / Ambient temperature

With potassium hydroxide; iodine; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; pentane;
DOI:10.1039/p19960000459