Technology Process of phenylmethyl 5-bromo-2-[(phenylmethyl)oxy]-4-(1-piperidinylcarbonyl)benzoate
There total 9 articles about phenylmethyl 5-bromo-2-[(phenylmethyl)oxy]-4-(1-piperidinylcarbonyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
for 18h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: thionyl chloride / 24 h / 50 °C
2: bromine / chloroform / 1 h / 0 °C
3: pyridine / 4 h
4: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C
5: water; calcium carbonate / 1,4-dioxane / 3 h / 150 °C
6: potassium carbonate / N,N-dimethyl-formamide / 21 h / 50 °C
7: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C
8: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h
With
pyridine; sodium chlorite; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; potassium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate;
dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; tetrachloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: bromine / chloroform / 1 h / 0 °C
2: pyridine / 4 h
3: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C
4: water; calcium carbonate / 1,4-dioxane / 3 h / 150 °C
5: potassium carbonate / N,N-dimethyl-formamide / 21 h / 50 °C
6: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C
7: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h
With
pyridine; sodium chlorite; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; potassium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate;
dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; tetrachloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
