(R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide

Base Information

• Chemical Name: (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide
• CAS No.: 875210-73-4
• Molecular Formula: C₂₁H₂₄BrCl₂N₃O₄
• Molecular Weight: 533.249
• Mol file: 875210-73-4.mol

Synonyms:(R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide

Chemical Property of (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide

There total 1 articles about (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2,2-dimethoxy-ethyl)-carbamic acid phenyl ester (875210-74-5) + (2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide (302840-67-1) → (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide (875210-73-4)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 60 ℃; for 5h;

Reference yield: 95.0%

(R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide (875210-73-4) → (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one (321656-72-8)

Guidance literature:

With 3,5-bis-trifluromethylphenylboronic acid; trimethyl orthoformate; In toluene; for 16h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2011.03.007

Reference yield: 94.0%

tetrachloromethane (56-23-5) + (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide (875210-73-4) → (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one (321656-72-8)

Guidance literature:

tetrachloromethane; (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide; With triethylamine; triphenylphosphine; In acetonitrile; at 20 ℃; for 3h;

With toluene-4-sulfonic acid; In acetonitrile; at 70 ℃; for 2h;

With sodium carbonate; sodium chloride; In Isopropyl acetate; water;

upstream raw materials:

(2,2-dimethoxy-ethyl)-carbamic acid phenyl ester

(2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide

Downstream raw materials:

(R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one