tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Base Information

Chemical Name:tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate
CAS No.:1020666-21-0
Molecular Formula:C₂₈H₂₉Cl₂N₃O₈
Molecular Weight:606.46
Hs Code.:

Synonyms:tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

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Chemical Property of tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

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Technology Process of tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

There total 1 articles about tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 125347-81-1
pyrrolidine-1,2,2-tricarboxylic acid 1-tert-butyl ester 2,2-diethyl ester

: 1020666-11-8
(S)-3-[4-(2,6-dichlorobenzyloxy)-phenyl]-2-ureidopropionic acid

: 1020666-21-0
tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 20h;
DOI:10.1021/jo702573z

Reference yield: 89.0%

: 1020666-21-0
tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

: 115-20-8
1,1,1-trichloroethanol

: 1020666-30-1
tert-butyl 7-{(S)-2-[4-(2,6-dichlorobenzyloxy)phenyl]-1-(2,2,2-trichloroethoxycarbonyl)-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jo702573z

Reference yield:

: 1020666-21-0
tert-butyl 7-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

: 593-51-1
methylamine hydrochloride

: 1020666-27-6
tert-butyl (5S)-7-{(S)-2-[4-(2,6-dichlorobenzyloxy)-phenyl]-1-methylcarbamoylethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

: 1020666-26-5
tert-butyl (5R)-7-{(S)-2-[4-(2,6-dichlorobenzyloxy)-phenyl]-1-methylcarbamoylethyl}-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;
DOI:10.1021/jo702573z