2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

Base Information

Chemical Name:2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine
CAS No.:1198744-88-5
Molecular Formula:C₂₂H₂₆N₂O₅
Molecular Weight:398.459
Hs Code.:

Synonyms:2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

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Chemical Property of 2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

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Technology Process of 2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

There total 7 articles about 2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-38-5
p-Iodophenol

: 1198744-88-5
2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

: 1198744-89-6
2-((1-methylethyl)oxy)-4-((2R)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(I) oxide / N,N-dimethyl-formamide / 15 h / 110 °C

2.1: potassium carbonate / acetone / 4 h / 65 °C

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 20 °C

3.2: pH 2 - 3

4.1: triethylamine / tetrahydrofuran / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.5 h / 20 °C

7.1: Chiral Pack AD-H column / Resolution of racemate

With copper(I) oxide; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene; 6.1: Mitsunobu reaction;

Reference yield:

: 1030828-96-6
5-[4-(benzyloxy)phenyl]-1,2-oxazol-3-ol

: 1198744-88-5
2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

: 1198744-89-6
2-((1-methylethyl)oxy)-4-((2R)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

3: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.5 h / 20 °C

4: Chiral Pack AD-H column / Resolution of racemate

With hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene; 3: Mitsunobu reaction;

Reference yield:

: 1030828-97-7
5-[4-(benzyloxy)phenyl]-3-(methoxymethoxy)-1,2-oxazole

: 1198744-88-5
2-((1-methylethyl)oxy)-4-((2S)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

: 1198744-89-6
2-((1-methylethyl)oxy)-4-((2R)-2-((4-(3-(((methyloxy)methyl)oxy)isoxazol-5-yl)phenyl)oxy)propyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

2: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.5 h / 20 °C

3: Chiral Pack AD-H column / Resolution of racemate

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene; 2: Mitsunobu reaction;