methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

Base Information

Chemical Name:methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate
CAS No.:145300-78-3
Molecular Formula:C₃₄H₄₉NO₄Si
Molecular Weight:563.853
Hs Code.:

methyl 3-<1-hydroxy-2-<7-<1-<<dimethyl(1,1-dimethylethyl)silyl>oxy>nonyl>quinolin-2-yl>ethyl>benzoate

Synonyms:methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

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Chemical Property of methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

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Technology Process of methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

There total 8 articles about methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 145300-53-4
2-<7-<1-<oxy>nonyl>quinolin-2-yl>-1-<3-<<(trifluoromethyl)sulfonyl>oxy>phenyl>ethanol

: 145300-78-3
methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

Guidance literature:: With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In dimethyl sulfoxide; at 70 ℃; for 32h;
DOI:10.1021/jm00074a012

Reference yield:

: 612-60-2
7-methylquinoline

: 145300-78-3
methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 46 percent / SeO₂ / 12 h / 150 - 155 °C

2: 1.) Mg / 1.) THF, reflux, 2.) THF, from -15 deg C to RT

3: 100 percent / 2,6-lutidine / CH₂Cl₂ / -10 - 20 °C

4: 40 percent / TMEDA, O₂ / tetrahydrofuran / 1 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h

6: 30 percent / Et₃N, Pd(OAc)2, dppp / dimethylsulfoxide / 32 h / 70 °C

With 2,6-dimethylpyridine; palladium diacetate; n-butyllithium; selenium(IV) oxide; N,N,N,N,-tetramethylethylenediamine; 1,3-bis-(diphenylphosphino)propane; oxygen; magnesium; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00074a012

Reference yield:

: 49573-30-0
quinoline-7-carbaldehyde

: 145300-78-3
methyl 3-<1-hydroxy-2-<7-<1-<oxy>nonyl>quinolin-2-yl>ethyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg / 1.) THF, reflux, 2.) THF, from -15 deg C to RT

2: 100 percent / 2,6-lutidine / CH₂Cl₂ / -10 - 20 °C

3: 40 percent / TMEDA, O₂ / tetrahydrofuran / 1 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h

5: 30 percent / Et₃N, Pd(OAc)2, dppp / dimethylsulfoxide / 32 h / 70 °C

With 2,6-dimethylpyridine; palladium diacetate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 1,3-bis-(diphenylphosphino)propane; oxygen; magnesium; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00074a012