carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester

Base Information

• Chemical Name: carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester
• CAS No.: 929535-88-6
• Molecular Formula: C₂₉H₃₈N₄O₁₁
• Molecular Weight: 618.641
• Mol file: 929535-88-6.mol

Synonyms:carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester

Chemical Property of carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester

There total 3 articles about carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

{2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester (929535-87-5) + 4-Nitrophenyl chloroformate (7693-46-1) → carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester (929535-88-6)

Guidance literature:

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/chem.200601263

Reference yield:

bis(2-tert-butyloxycarbonylaminoethyl)amine (117499-16-8) → carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester (929535-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NEt₃ / dimethylformamide / 2 h / 20 °C

2: 60 percent / N,N-diisopropyl ethylamine; pyridine / tetrahydrofuran / 1 h / 20 °C

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.200601263

Reference yield:

carbonic acid 4-hydroxymethylphenyl ester 4-nitrophenyl ester (334999-60-9) → carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester (929535-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NEt₃ / dimethylformamide / 2 h / 20 °C

2: 60 percent / N,N-diisopropyl ethylamine; pyridine / tetrahydrofuran / 1 h / 20 °C

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.200601263

upstream raw materials:

{2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester

4-Nitrophenyl chloroformate

bis(2-tert-butyloxycarbonylaminoethyl)amine

carbonic acid 4-hydroxymethylphenyl ester 4-nitrophenyl ester

Downstream raw materials:

methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester