(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

Base Information

Chemical Name:(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid
CAS No.:1403506-16-0
Molecular Formula:C₂₄H₂₅ClN₄O₈S
Molecular Weight:565.004
Hs Code.:

Synonyms:(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

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Chemical Property of (S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

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Technology Process of (S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

There total 12 articles about (S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-30-5
succinic acid anhydride

: 1403506-12-6
(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

: 1403506-16-0
(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

Guidance literature:: In toluene; at 110 ℃; for 2h;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1403506-16-0
(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / 1 h / 20 - 100 °C

2.1: sodium hydroxide / water / 0.17 h / 10 - 20 °C

2.2: 15 h / 45 - 50 °C

3.1: ammonium formate / palladium 10% on activated carbon / 1 h / 20 °C / Reflux; Cooling with dry ice

4.1: triethylamine / dichloromethane / 4 h

5.1: ammonium chloride; iron / ethanol / 80 - 85 °C

6.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube

7.1: toluene / 2 h / 110 °C

With ammonia; ammonium formate; tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 89-63-4
4-Chloro-2-nitroaniline

: 1403506-16-0
(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol; water / 0 - 10 °C / Industry scale

1.2: 0.5 h / -5 - 0 °C

2.1: Polyphosphoric acid (PPA) / 110 °C

3.1: acetic anhydride; sulfuric acid / 0 - 20 °C

3.2: 0 - 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 10 °C

5.1: triethylamine / dichloromethane / 4 h

6.1: ammonium chloride; iron / ethanol / 80 - 85 °C

7.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube

8.1: toluene / 2 h / 110 °C

With oxalyl dichloride; sulfuric acid; ammonia; acetic anhydride; iron; ammonium chloride; triethylamine; potassium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; isopropyl alcohol; toluene;