2,6-DifluoroBenzeneBoronicacid,pinacolester

Base Information

• Chemical Name: 2,6-DifluoroBenzeneBoronicacid,pinacolester
• CAS No.: 863868-37-5
• Molecular Formula: C₁₂H₁₅BF₂O₂
• Molecular Weight: 240.058
• Hs Code.: 2934999090
• Mol file: 863868-37-5.mol

Synonyms:2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaBorolane;2,6-DifluoroBenzeneBoronicacid,pinacolester;2,6-Difluorophenylboronic acid, pinacol ester

Chemical Property of 2,6-DifluoroBenzeneBoronicacid,pinacolester

Chemical Property:

• Vapor Pressure: 0.00599mmHg at 25°C
• Refractive Index: 1.468
• Boiling Point: 281.7°C at 760 mmHg
• Flash Point: 124.2°C
• PSA: 18.46000
• Density: 1.11g/cm³
• LogP: 2.26400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,6-Difluorophenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DifluoroBenzeneBoronicacid,pinacolester

There total 11 articles about 2,6-DifluoroBenzeneBoronicacid,pinacolester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + 2,6-difluorophenylboronic acid (162101-25-9) → 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (863868-37-5)

Guidance literature:

In toluene; for 16h; Reflux;

Reference yield: 92.0%

1-chloro-2,6-difluorobenzene (38361-37-4) + bis(pinacol)diborane (73183-34-3) → 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (863868-37-5)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 105 ℃; for 18h; Reagent/catalyst; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.202004648

Reference yield: 79.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + 2,6-difluorophenylboronic acid (162101-25-9) → 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (863868-37-5) + water (7732-18-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 16h; Solvent; Equilibrium constant;

DOI:10.1021/jacs.1c06863

upstream raw materials:

1-bromo-2,6-difluorobenzene

bis(pinacol)diborane

1,3-Difluorobenzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

Downstream raw materials:

3-(2,6-difluorophenyl)-1-ethyl-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

2,2’,6,6’-tetrafluoroazobenzene