N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one

Base Information

• Chemical Name: N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one
• CAS No.: 111492-86-5
• Molecular Formula: C₁₈H₁₆N₂O
• Molecular Weight: 276.338
• Mol file: 111492-86-5.mol

Synonyms:N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one

Chemical Property of N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one

There total 15 articles about N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylhydrazine (100-63-0) + 1-(phenylmethyl)-2,3-piperidinedione (111492-69-4) → Nb-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one (111492-86-5)

Guidance literature:

phenylhydrazine; 1-(phenylmethyl)-2,3-piperidinedione; In toluene; at 80 ℃;

With formic acid; at 80 ℃;

DOI:10.1021/acs.joc.8b01424

Reference yield: 86.0%

N-benzyl tryptamine (15741-79-4) + benzene-1,3,5-triyl triformate → Nb-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one (111492-86-5)

Guidance literature:

With palladium(II) trifluoroacetate; copper diacetate; triethylamine; In dimethyl sulfoxide; toluene; at 110 ℃; for 20h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b02114

Reference yield: 85.0%

methyl Nb-benzyl-1,2,3,4-tetrahydrocarboline-1-carboxylate → Nb-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one (111492-86-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0040-4039(01)00482-8

upstream raw materials:

4,9-Dihydropyrano<3,4-b>indol-1(3H)-on

benzylamine

1-benzyl-3-phenylhydrazono-2-piperidone

dihydroxypyridine

Downstream raw materials:

2,3,4,9-Tetrahydro-2-(2-phenylmethyl)-1H-pyrido<3,4-b>indole

2-benzyl-2,3,4,9-tetrahydro-β-carboline-1-thione

(2-benzyl-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

(2-benzyl-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid