Technology Process of methyl 2-{[(benzyloxy)carbonyl]amino}-3-[4-(hydroxymethyl)phenyl]propanoate
There total 5 articles about methyl 2-{[(benzyloxy)carbonyl]amino}-3-[4-(hydroxymethyl)phenyl]propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
Cooling with ice;
DOI:10.1016/j.bmc.2010.09.040
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium carbonate / water; acetone / 3 h / 20 °C
2: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere
3: potassium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere
4: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Cooling with ice
With
dimethylsulfide borane complex; sodium carbonate; potassium carbonate; triethylamine;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / 0.08 h / 0 °C / Inert atmosphere
1.2: 21 h / 0 - 20 °C
2.1: sodium carbonate / water; acetone / 3 h / 20 °C
3.1: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere
4.1: potassium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere
5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Cooling with ice
With
thionyl chloride; dimethylsulfide borane complex; sodium carbonate; potassium carbonate; triethylamine;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; acetonitrile;
