4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Base Information

Chemical Name:4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester
CAS No.:1261154-05-5
Molecular Formula:C₂₁H₂₆NO₈P
Molecular Weight:451.413
Hs Code.:

Synonyms:4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Suppliers and Price of 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

There total 7 articles about 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868-85-9
Dimethyl phosphite

: 183021-90-1
methyl 2-{[(benzyloxy)carbonyl]amino}-3-(4-formylphenyl)propanoate

: 1261154-05-5
4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Guidance literature:: With cesium fluoride; Heating;
DOI:10.1016/j.bmc.2010.09.040

Reference yield:

: 183021-88-7
methyl 2-{[(benzyloxy)carbonyl]amino}-3-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanoate

: 1261154-05-5
4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 1 h

4: cesium fluoride / 1 h

With dimethylsulfide borane complex; potassium carbonate; cesium fluoride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 1261154-05-5
4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(phenylmethoxy)carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: potassium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

3: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 1 h

5: cesium fluoride / 1 h

With dimethylsulfide borane complex; potassium carbonate; triethylamine; cesium fluoride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;