(4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Base Information

Chemical Name:(4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester
CAS No.:82310-53-0
Molecular Formula:C₂₇H₃₅NO₅
Molecular Weight:453.579
Hs Code.:

Synonyms:(4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

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Chemical Property of (4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

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Technology Process of (4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

There total 29 articles about (4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 82310-90-5
(4R,5R)-(+)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

: 82310-53-0
(4R,5R)-(+)-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetone; for 26h; Heating;

Reference yield: 72.0%

: 100-39-0
benzyl bromide

: 73053-71-1,82310-52-9,82310-90-5
(+/-)-trans-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

: 73053-72-2,82310-53-0
(+/-)-trans-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetone; for 48h; Heating;

Reference yield:

: 55676-25-0
3-(2-methyl-[1,3]dioxolan-2-yl)-pyridine

: 73053-72-2,82310-53-0
(+/-)-trans-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 13.2 g / benzene / 72 h / Heating

2: K₃Fe(CN)6, KOH / H₂O; benzene / 5 h / 32 °C

3: 99 percent / H₂ / Raney Ni W-2 / ethanol / 22 h / Ambient temperature

4: 98 percent / aq. HCl (10percent) / ethanol / 2 h / 50 °C

5: 92 percent / aq. hydrazine hydrate (80percent), KOH / ethane-1,2-diol / 1.) 120 deg C, 1 h; 2.) 190 deg C, 3.5 h

6: 94 percent / K₂CO₃ / acetone / 24 h / Heating

7: 70 percent / lithium diisopropylamide (LDA), hexamethylphosphoramide (HMPA) / tetrahydrofuran / 2 h / -78 °C

8: sodium metaperiodate (NaIO₄) / methanol; H₂O / 24 h / Ambient temperature

9: CaCO₃ / toluene / 1 h / Heating

10: 1.) Na-EtOH; 2.) aq. NaOH (2N) / 1.) EtOH, 70 deg C, 2 h, reflux, 6 h; 2.) EtOH, 50 deg C, 20 h

11: 65 percent / aq. AcOH (60percent) / 6 h / Heating

12: 89 percent / HCl / 24 h / Ambient temperature

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; sodium periodate; ethanol; hydrogen; sodium; potassium carbonate; hydrazine hydrate; acetic acid; calcium carbonate; potassium hexacyanoferrate(III); lithium diisopropyl amide; Raney Ni W-2; In tetrahydrofuran; methanol; ethanol; water; ethylene glycol; acetone; toluene; benzene;