1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-, Methyl ester

Base Information

• Chemical Name: 1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-, Methyl ester
• CAS No.: 25947-14-2
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.212
• Mol file: 25947-14-2.mol

Synonyms:methyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate

Chemical Property of 1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-, Methyl ester

Chemical Property:

• PKA: 11.60±0.40(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

methyl(4-oxo-3,4-dihydrophthalazin-1-yl)acetate ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-, Methyl ester

There total 5 articles about 1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

methanol (67-56-1) + 1,2-Dihydro-1-oxophthalazin-4-ylacetic acid (25947-11-9) → methyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate (25947-14-2)

Guidance literature:

With thionyl chloride; at 75 ℃; for 6h;

DOI:10.1021/acs.jmedchem.1c01066

Reference yield: 61.0%

1,2-Dihydro-1-oxophthalazin-4-ylacetic acid (25947-11-9) + methyl iodide (74-88-4) → methyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate (25947-14-2)

Guidance literature:

With potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; for 1h; Ambient temperature;

Reference yield:

phthalic anhydride (85-44-9) → methyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate (25947-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium acetate / 135 - 140 °C

2: hydrazine hydrate / methanol / Reflux

3: sulfuric acid

With sulfuric acid; potassium acetate; hydrazine hydrate; In methanol;

DOI:10.1590/S0103-50532011000500006

upstream raw materials:

1,2-Dihydro-1-oxophthalazin-4-ylacetic acid

methyl iodide

methanol

phthalic anhydride

Downstream raw materials:

{3-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid methyl ester

{3-[3-(2,3-Difluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid methyl ester

methyl 2-(3-((3-(4-bromo-3-fluorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

methyl 2-(3-((3-(1-benzylpiperidin-4-yl)-4,5-dihydro-isoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

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