1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Base Information

Chemical Name:1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile
CAS No.:1542705-09-8
Molecular Formula:C₂₄H₂₂N₆
Molecular Weight:394.479
Hs Code.:

Synonyms:1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

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Chemical Property of 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

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Technology Process of 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

There total 15 articles about 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1542705-09-8
1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: sodium methylate / methanol / 48 h / Reflux

2: trichlorophosphate / 3 h / Reflux

3: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Reflux

4: triethylamine / dichloromethane / 2 h

5: triethylamine / acetonitrile / 20 °C

6: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

7: trifluoroacetic acid / dichloromethane / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; caesium carbonate; triethylamine; trifluoroacetic acid; XPhos; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: N-tert-butyl 4-(benzylamino)-2-(4-cyano-2-methyl-1H-indol-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

: 1542705-09-8
1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diol

: 1542705-09-8
1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 3 h / Reflux

2: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Reflux

3: triethylamine / dichloromethane / 2 h

4: triethylamine / acetonitrile / 20 °C

5: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; caesium carbonate; triethylamine; trifluoroacetic acid; XPhos; trichlorophosphate; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01346